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Mechanochemical Synthesis of Functionalized Quinolines by Iodine Mediated Oxidative Annulation
Author(s) -
Halder Atreyee,
Maiti Debabrata,
De Sarkar Suman
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901758
Subject(s) - annulation , quinoline , iodine , aniline , chemistry , combinatorial chemistry , solvent , yield (engineering) , oxidative phosphorylation , organic chemistry , activator (genetics) , molecule , environmentally friendly , catalysis , materials science , biochemistry , metallurgy , gene , ecology , biology
An iodine‐mediated environmentally benign synthesis of multi‐substituted quinoline derivatives is developed using a solvent‐free mechanochemical process. Appropriately designed and easily accessible protecting group‐free aniline derivatives were used for the oxidative annulation reaction, and a series of quinoline derivatives with variable functionalities were synthesized up to 89 % isolated yield. Importantly, the activator iodine remains in the quinoline molecule and promotes further functionalizations. The present methodology is beneficial with regard to operational simplicity and mild reaction conditions.