Rhodium(I)/Chiral Diene‐Catalyzed Enantioselective Addition of Boronic Acids to  N ‐Unsubstituted Isatin‐Derived Ketimines | Zendy

Yonesaki Ryohei | Zendy; Kusagawa Ibuki | Zendy; Morimoto Hiroyuki | Zendy; Hayashi Tamio | Zendy; Ohshima Takashi | Zendy

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Rhodium(I)/Chiral Diene‐Catalyzed Enantioselective Addition of Boronic Acids to N ‐Unsubstituted Isatin‐Derived Ketimines

Author(s) -

Yonesaki Ryohei,

Kusagawa Ibuki,

Morimoto Hiroyuki,

Hayashi Tamio,

Ohshima Takashi

Publication year - 2020

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201901745

Subject(s) - enantioselective synthesis , isatin , rhodium , diene , chemistry , catalysis , yield (engineering) , organic chemistry , adduct , combinatorial chemistry , materials science , natural rubber , metallurgy

Enantioselective addition of boronic acids to N ‐unsubstituted isatin‐derived ketimines was realized using rhodium(I)/chiral diene catalysts. The reactions can be performed in the presence of catalytic amounts of a base to give adducts in high yield with high enantioselectivity. Preliminary mechanistic information including a computational model to explain the observed enantioselectivity is also provided.

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