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Design and Synthesis of Zn II ‐Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi‐drug Delivery
Author(s) -
Bera Sourabh,
Chowdhury Abhinanda,
Sarkar Koushik,
Dastidar Parthasarathi
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901664
Subject(s) - mefenamic acid , naproxen , calcein , flurbiprofen , chemistry , ibuprofen , drug delivery , doxorubicin hydrochloride , nuclear chemistry , mtt assay , fluorescence , stereochemistry , doxorubicin , in vitro , organic chemistry , biochemistry , pharmacology , chromatography , medicine , alternative medicine , surgery , pathology , chemotherapy , membrane , physics , quantum mechanics
A series of coordination polymers synthesized from a bis‐pyridyl linker, namely 4,4′‐azopyridine ( L ), selected non‐steroidal‐anti‐inflammatory drugs (NSAIDs), namely diclofenac ( Dic ), ibuprofen ( Ibu ), flurbiprofen ( Flu ), mefenamic acid ( Mefe ), and naproxen ( Nap ), and Zn(NO 3 ) 2 were characterized by single crystal X‐ray diffraction. One of the coordination polymers, namely CP3 derived from Flu , was able to form metallovesicles in DMSO, DMSO/H 2 O and DMSO/DMEM (biological media) as revealed by TEM, AFM and DLS. Metallovesicle formation by CP3 was further supported by loading a fluorescent dye, namely calcein, as well as an anti‐cancer drug, doxorubicin hydrochloride ( DOX ), as revealed by UV‐vis and emission spectra, and fluorescence microscopy. DOX ‐loaded metallovesicles of CP3 ( DOX@CP3‐vesicle ) could be delivered in vitro to a highly aggressive human breast cancer cell line, namely MDA‐MB‐231, as revealed by MTT and cell migration assays, and also cell imaging performed under laser scanning confocal microscope (LSCM). Thus, a proof of concept for developing a multi‐drug delivery system derived from a metallovesicle for delivering an anti‐cancer drug to cancer cells is demonstrated for the first time.