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Facile Synthesis of Polysubstituted Indolizines via One‐Pot Reaction of 1‐Acetylaryl 2‐Formylpyrroles and Enals
Author(s) -
Gong Minghua,
Guo Jingcheng,
Jiang Pengrui,
Zhang Ye,
Fu Zhenqian,
Huang Wei
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901517
Subject(s) - aromatization , annulation , functional group , scope (computer science) , chemistry , substrate (aquarium) , reaction conditions , pyridine , combinatorial chemistry , transformation (genetics) , oxidative phosphorylation , organic chemistry , catalysis , computer science , biochemistry , oceanography , gene , programming language , geology , polymer
An efficient method for the synthesis of polysubstituted indolizines has been developed based on formal [4+2] annulation of 1‐acetylaryl 2‐formylpyrroles with enals, followed by oxidative aromatization. Pyridine‐type six‐membered rings were constructed in this transformation. This transition metal‐free reaction features mild reaction conditions, a broad substrate scope, and excellent functional group tolerance. Notably, the formyl group is well tolerated under reaction conditions.