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Ag@TiO 2 Nanoprisms with Highly Efficient Near‐Infrared Photothermal Conversion for Melanoma Therapy
Author(s) -
Nie Chuang,
Du Peng,
Zhao Hongwei,
Xie Hainan,
Li Yuxin,
Yao Li,
Shi Yuanyuan,
Hu Lianna,
Si Shaoyan,
Zhang Maonian,
Gu Jianwen,
Luo Ling,
Sun Zaicheng
Publication year - 2020
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901394
Subject(s) - photothermal therapy , biocompatibility , irradiation , cytotoxicity , photothermal effect , in vivo , materials science , melanoma , nanotechnology , in vitro , chemistry , cancer research , medicine , biochemistry , physics , microbiology and biotechnology , nuclear physics , metallurgy , biology
Abstract Melanoma is a primary reason of death from skin cancer and associated with high lethality. Photothermal therapy (PTT) has been developed into a powerful cancer treatment technique in recent years. Here, we created a low‐cost and high‐performance PTT agent, Ag@TiO 2 NPs, which possesses a high photothermal conversion efficiency of ≈65 % and strong near‐infrared (NIR) absorption about 808 nm. Ag NPs were synthesized using a two‐step method and coated with TiO 2 to obtain Ag@TiO 2 NPs by a facile sol‐gel method. Because of the oxide, Ag@TiO 2 NPs exhibit remarkable high photothermal conversion efficiencies and biocompatibility in vivo and in vitro. Cytotoxicity and therapeutic efficiency of photothermal cytotoxicity of Ag@TiO 2 NPs were tested in B16‐F10 cells and C57BL/6J mice. Under light irradiation, the elevated temperature causes cell death in Ag NPs‐treated (100 μg mL −1 ) cells in vitro (both p <0.01). In the case of subcutaneous melanoma tumor model, Ag@TiO 2 NPs (100 μg mL −1 ) were injected into the tumor and irradiated with a 808 nm laser of 2 W cm −2 for 1 minute. As a consequence, the tumor volume gradually decreased by NIR laser irradiation with only a single treatment. The results demonstrate that Ag@TiO 2 NPs are biocompatible and an attractive photothermal agent for cutaneous melanoma by local delivery.