Copper‐Catalyzed Electrophilic Cyclization of  N ‐Propargylamines with Sodium Sulfinate for the Synthesis of 3‐Sulfonated Quinolines | Zendy

Li Ling | Zendy; Zhang XingGuo | Zendy; Hu BoLun | Zendy; Zhang XiaoHong | Zendy

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Copper‐Catalyzed Electrophilic Cyclization of N ‐Propargylamines with Sodium Sulfinate for the Synthesis of 3‐Sulfonated Quinolines

Author(s) -

Li Ling,

Zhang XingGuo,

Hu BoLun,

Zhang XiaoHong

Publication year - 2019

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201901298

Subject(s) - electrophile , aromatization , chemistry , reagent , catalysis , sodium , combinatorial chemistry , copper , cascade , organic chemistry , chromatography

A convenient and effective protocol for the synthesis of 3‐sulfonated quinolines via copper‐catalyzed electrophilic cyclization of N ‐propargylamines has been developed, in which cheap and stable sodium sulfinates were utilized as green sulfonylation reagents. This cascade transformation involves radical addition, cyclization and dehydrogenative aromatization processes in a one‐pot reaction under mild conditions.

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