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Copper‐Catalyzed Electrophilic Cyclization of N ‐Propargylamines with Sodium Sulfinate for the Synthesis of 3‐Sulfonated Quinolines
Author(s) -
Li Ling,
Zhang XingGuo,
Hu BoLun,
Zhang XiaoHong
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901298
Subject(s) - electrophile , aromatization , chemistry , reagent , catalysis , sodium , combinatorial chemistry , copper , cascade , organic chemistry , chromatography
Abstract A convenient and effective protocol for the synthesis of 3‐sulfonated quinolines via copper‐catalyzed electrophilic cyclization of N ‐propargylamines has been developed, in which cheap and stable sodium sulfinates were utilized as green sulfonylation reagents. This cascade transformation involves radical addition, cyclization and dehydrogenative aromatization processes in a one‐pot reaction under mild conditions.