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Effects of Physical Damage in the Intermediate Phase on the Progression of Amyloid β Fibrillization
Author(s) -
Tashiro Ryu,
Taguchi Hiroaki,
Hidaka Kumi,
Endo Masayuki,
Sugiyama Hiroshi
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901193
Subject(s) - amyloid (mycology) , biophysics , amyloid fibril , fibril , chemistry , amyloid β , biochemistry , disease , biology , medicine , pathology , inorganic chemistry
Understanding the mechanism responsible for the progression of amyloid deposition is important for developing methods to suppress this process in the treatment of Alzheimer's disease. The effects of physical damage during the transition phase of amyloid β fibril formation are unclear. In this study, we used high‐speed atomic force microscopy to investigate the effects of damage to the intermediates of amyloid β in real time. Physical damage to intermediates did not suppress, but instead promoted fibrillization. This progression was accompanied by morphological changes from globular oligomers to protofibrils. These results suggest that the properties of the intermediates, such as structural fragility and stability, are highly related to the rate of fibrillization.