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Synthetic Strategies for (−)‐Cannabidiol and Its Structural Analogs
Author(s) -
Jung Byunghyuck,
Lee Jungkyu K.,
Kim Jungnam,
Kang Eunhye K.,
Han Sang Yeong,
Lee HeeYoon,
Choi Insung S.
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901179
Subject(s) - cannabidiol , neuroprotection , cannabis , pharmacology , medicine , psychiatry
(−)‐Cannabidiol ((−)‐CBD), a non‐psychoactive phytocannabinoid from Cannabis , and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti‐epileptic, anti‐inflammatory, anxiolytic, and anti‐cancer properties. (−)‐CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction‐based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical‐synthetic strategies for (−)‐CBD could tackle these issues, and, additionally, generate novel (−)‐CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (−)‐CBD and its analogs.