Synthetic Strategies for (−)‐Cannabidiol and Its Structural Analogs | Zendy

Jung Byunghyuck | Zendy; Lee Jungkyu K. | Zendy; Kim Jungnam | Zendy; Kang Eunhye K. | Zendy; Han Sang Yeong | Zendy; Lee HeeYoon | Zendy; Choi Insung S. | Zendy

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Synthetic Strategies for (−)‐Cannabidiol and Its Structural Analogs

Author(s) -

Jung Byunghyuck,

Lee Jungkyu K.,

Kim Jungnam,

Kang Eunhye K.,

Han Sang Yeong,

Lee HeeYoon,

Choi Insung S.

Publication year - 2019

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201901179

Subject(s) - cannabidiol , neuroprotection , cannabis , pharmacology , medicine , psychiatry

(−)‐Cannabidiol ((−)‐CBD), a non‐psychoactive phytocannabinoid from Cannabis , and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti‐epileptic, anti‐inflammatory, anxiolytic, and anti‐cancer properties. (−)‐CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction‐based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical‐synthetic strategies for (−)‐CBD could tackle these issues, and, additionally, generate novel (−)‐CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (−)‐CBD and its analogs.

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