Premium
Design and Applications of Small Molecular Probes for Calcium Detection
Author(s) -
Kumar Naresh,
Kumar Manoj,
Bhalla Vandana
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901149
Subject(s) - calcium , fluorescence , chelation , in vivo , chemistry , molecular probe , biophysics , nanotechnology , in vitro , small molecule , calcium signaling , biochemistry , materials science , biology , inorganic chemistry , microbiology and biotechnology , dna , physics , organic chemistry , quantum mechanics
The physiological significance of calcium ions such as the role in cellular signalling, cell growth, etc. have driven the development of methods to detect and monitor the level of Ca 2+ ions, both in vivo and in vitro. Although various approaches for the detection of calcium ions have been reported, methods based on small molecular fluorescent probes have unique advantages including small probe size, easy monitoring of detection processes and applicability in biological systems. In this review article, we will discuss the progress in the development of Ca 2+ ‐binding fluorescent probes by taking into account the types of chelating groups that have been employed for Ca 2+ binding.