Premium
Beyond the Corey–Chaykovsky Reaction: Synthesis of Unusual Cyclopropanoids via Desymmetrization and Thereof
Author(s) -
Patel Kaushalendra,
Mishra Uttam K.,
Mukhopadhyay Dipto,
Ramasastry S. S. V.
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901108
Subject(s) - desymmetrization , cyclopropane , chemistry , reagent , ring (chemistry) , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , enantioselective synthesis
Abstract Desymmetrization‐based protocols for the synthesis of highly functionalized indeno‐spirocyclopropanes and cyclopropa‐fused indanes have been established through unexpected reactions triggered by the Corey–Chaykovsky reagent. These structures were further elaborated in one step to privileged scaffolds such as fluorenones, indenones, and naphthaphenones. For instance, an acid‐catalyzed transformation of indeno‐spirocyclopropanes provided fluorenones via a homo‐Nazarov‐type cyclization, and naphthaphenones were obtained via an acid‐catalyzed cyclopropane ring‐opening/retro‐Michael sequence.