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Synthesis of Phenolic Compounds via Palladium Catalyzed C−H Functionalization of Arenes
Author(s) -
Saha Debajyoti,
Das Prasenjit,
Biswas Promita,
Guin Joyram
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901073
Subject(s) - catalysis , chemistry , trifluoroacetic acid , palladium , trifluoroacetic anhydride , hydroxylation , organic chemistry , surface modification , phenol , transition metal , phenols , combinatorial chemistry , organic synthesis , enzyme
Phenol and its derivatives are extremely useful compounds in organic synthesis, medicinal chemistry and material sciences. The synthesis of phenols involving selective construction of the C−O bond at a C−H bond of arenes using transition‐metal catalysis represents the most appealing strategy. Indeed, active research is currently going on for the synthesis of valuable phenolic compounds using a transition‐metal‐catalyzed C−H functionalization strategy. This short review summarizes recent advances on palladium‐catalyzed C−O bond forming reactions that enable direct access to phenolic compounds. These catalytic reactions proceed either via C−H esterification with trifluoroacetic acid/trifluoroacetic anhydride followed by in situ hydrolysis of the ester or via direct C−H hydroxylation. A brief analysis of substrate scope and limitation, reaction mechanism as well as synthetic utility of these reactions has been included.