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Exploiting Strained Rings in Chelation Guided C−H Functionalization: Integration of C−H Activation with Ring Cleavage
Author(s) -
Shah Tariq A.,
De Pinaki Bhusan,
Pradhan Sourav,
Banerjee Sonbidya,
Punniyamurthy Tharmalingam
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201901067
Subject(s) - surface modification , chelation , ring (chemistry) , bond cleavage , ring strain , chemistry , combinatorial chemistry , cleavage (geology) , alkyl , organic synthesis , chemical space , stereochemistry , transition metal , materials science , catalysis , drug discovery , organic chemistry , biochemistry , fracture (geology) , composite material
Abstract Strained ring systems are regarded as privileged coupling partners in directed C−H bond functionalization and have emerged as a potential research area in organic synthesis. The inherent ring strain in these systems acts as a driving force, allowing the facile construction of diversified structural scaffolds via integrating C−H activation and ring‐scission. The mechanistic underpinnings allows the implementation of a plethora of C−H bonds across plentiful organic substrates, including the less reactive alkyl ones. Considering the synthetic space, this area will foster developments of novel synthetic methods in chelation guided C−H functionalization. This review will focus on recent developments in transition‐metal catalyzed chelation assisted concomitant C−H activation and ring scission of strained rings to attain molecular complexity.