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Zinc‐Catalysed Hydroboration of Terminal and Internal Alkynes
Author(s) -
Mandal Souvik,
Mandal Sayantan,
Geetharani K.
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900839
Subject(s) - hydroboration , chemoselectivity , regioselectivity , chemistry , catalysis , zinc , terminal (telecommunication) , trifluoromethanesulfonate , organic chemistry , combinatorial chemistry , medicinal chemistry , computer science , telecommunications
A regioselective hydroboration of alkynes has been developed by using commercially available zinc triflate as a catalyst, in the presence of catalytic amount of NaBHEt 3 . The reaction tolerates a wide range of terminal alkynes having several synthetically useful functional groups and proceeds regioselectively to furnish hydroborated products in moderate to excellent yields. This system shows moderate chemoselectivity towards terminal C≡C bond over terminal and internal C=C bond and internal C≡C bond.