Premium
Multicomponent Approach to Hydantoins and Thiohydantoins Involving a Deep Eutectic Solvent
Author(s) -
Kotha Sambasivarao,
Gupta Naveen K.,
Aswar Vikas R.
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900744
Subject(s) - thiourea , deep eutectic solvent , eutectic system , chemistry , urea , tartaric acid , solvent , component (thermodynamics) , combinatorial chemistry , organic chemistry , physics , alloy , citric acid , thermodynamics
We report an efficient synthetic strategy to diverse hydantoins and thiohydantoins involving a three‐component reaction with the aid of deep eutectic solvent. Here, N , N ′‐dimethyl urea and N , N ′‐dimethyl thiourea play a dual role as reactant and reaction medium along with l ‐(+)‐tartaric acid. The three‐component reaction provides an easy access to 5‐amino‐1,3‐dialkyl‐substituted hydantoins and thiohydantoins in good yields.