Premium
TFAA‐Catalyzed Annulation Synthesis of Spiro Pyrrolo[1,2‐ a ]quinoxaline Derivatives from 1‐(2‐Aminophenyl)pyrroles and Benzoquinones/Ketones
Author(s) -
Ni Jixiang,
Jiang Yong,
Qi Zhenjie,
Yan Rulong
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900567
Subject(s) - quinoxaline , annulation , chemistry , catalysis , nucleophile , combinatorial chemistry , medicinal chemistry , nucleophilic addition , organic chemistry
A metal‐free trifluorosulfonate anhydride (TFAA)‐catalyzed strategy for the synthesis of spiro pyrrolo[1,2‐a]quinoxalines from 1‐(2‐aminophenyl)pyrroles and benzoquinones/ketones has been developed. With this general method, spiro pyrrolo[1,2‐a]quinoxalines have been accessed via nucleophilic addition and cyclization. This reaction exhibits good functional group tolerance, and a wide range of products are obtained in moderate to good yields.