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Water‐soluble AIE‐Active Fluorescent Organic Nanoparticles: Design, Preparation and Application for Specific Detection of Cysteine over Homocysteine and Glutathione in Living Cells
Author(s) -
Ning Zhangwei,
Wu Songze,
Liu Guangjian,
Ji Yanming,
Jia Liyan,
Niu Xiaoxiao,
Ma Rongfang,
Zhang Yuan,
Xing Guowen
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900551
Subject(s) - moiety , fluorescence , chemistry , cysteine , tetraphenylethylene , amphiphile , nanoparticle , aldehyde , glutathione , combinatorial chemistry , organic chemistry , copolymer , nanotechnology , aggregation induced emission , materials science , quantum mechanics , catalysis , enzyme , polymer , physics
Water‐soluble ratiometric AIE‐active fluorescent organic nanoparticles 2OA‐FON for the specific sensing of cysteine over other biothiols are reported. The obtained amphiphilic probe included olefin aldehyde as recognizing unit, tetraphenylethylene as fluorescence reporter and lactose moiety as a hydrophilic group. This work provides a general design strategy based on the introduction of a sugar moiety into a hydrophobic AIEgen to develop ratiometric water‐soluble fluorescent organic nanoparticles.