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Assembly of Functionalized 4‐Alkynylisoxazoles by Palladium‐Catalyzed Three‐Component Cascade Cyclization/Alkynylation
Author(s) -
Li Jianxiao,
Huang Ruikang,
Li Can,
Lin Shao,
Wu Wanqing,
Jiang Huanfeng
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900476
Subject(s) - cascade , palladium , alkynylation , catalysis , carbene , combinatorial chemistry , chemistry , ionic bonding , component (thermodynamics) , ionic liquid , simplicity , organic chemistry , ion , physics , chromatography , quantum mechanics , thermodynamics
A novel N‐heterocyclic carbene (NHC)‐palladium‐catalyzed three‐component cascade cyclization/alkynylation for the synthesis of structurally diverse 4‐alkynylisoxazoles was efficiently developed in ionic liquids. The operational simplicity, without additives, no additional ligands, and 0.5 mol % catalyst loading under air are some of the attractive features of this present protocol.