Assembly of Functionalized 4‐Alkynylisoxazoles by Palladium‐Catalyzed Three‐Component Cascade Cyclization/Alkynylation | Zendy

Li Jianxiao | Zendy; Huang Ruikang | Zendy; Li Can | Zendy; Lin Shao | Zendy; Wu Wanqing | Zendy; Jiang Huanfeng | Zendy

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Assembly of Functionalized 4‐Alkynylisoxazoles by Palladium‐Catalyzed Three‐Component Cascade Cyclization/Alkynylation

Author(s) -

Li Jianxiao,

Huang Ruikang,

Li Can,

Lin Shao,

Wu Wanqing,

Jiang Huanfeng

Publication year - 2019

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201900476

Subject(s) - cascade , palladium , alkynylation , catalysis , carbene , combinatorial chemistry , chemistry , ionic bonding , component (thermodynamics) , ionic liquid , simplicity , organic chemistry , ion , physics , chromatography , quantum mechanics , thermodynamics

A novel N‐heterocyclic carbene (NHC)‐palladium‐catalyzed three‐component cascade cyclization/alkynylation for the synthesis of structurally diverse 4‐alkynylisoxazoles was efficiently developed in ionic liquids. The operational simplicity, without additives, no additional ligands, and 0.5 mol % catalyst loading under air are some of the attractive features of this present protocol.

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