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Photocatalyst‐free Synthesis of Indazolones under CO 2 Atmosphere
Author(s) -
Yang Tianbao,
Lu Huiai,
Qiu Renhua,
Hong Ling,
Yin ShuangFeng,
Kambe Nobuaki
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900306
Subject(s) - hela , photocatalysis , chemistry , amine gas treating , photochemistry , atmosphere (unit) , redox , methanol , combinatorial chemistry , carbamate , irradiation , organic chemistry , catalysis , cell , biochemistry , physics , thermodynamics , nuclear physics
A convenient photocatalyst‐free method for the synthesis of redox‐active 1,2‐dihydro‐3 H ‐indazol‐3‐one derivatives from (2‐nitroaryl)methanol and amines was developed. The reaction proceeded efficiently at room temperature by irradiation of UV light under CO 2 atmosphere (1.0 atm, flow) without any photocatalysts or additives. This mild, operationally simple method shows wide functional tolerance. The carbamate formed in situ from CO 2 and amine is proposed to be the key of this reaction. Some of these compounds synthesized by the present method were found to exhibit high anticancer activities, which can lower the viability of cancerous cell lines such as HeLa, MCF‐7 and U87.