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Cover Feature: Glycopolymers Mimicking GM1 Gangliosides: Cooperativity of Galactose and Neuraminic Acid for Cholera Toxin Recognition (Chem. Asian J. 7/2019)
Author(s) -
Terada Yuhei,
Hoshino Yu,
Miura Yoshiko
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900255
Subject(s) - neuraminic acid , cholera toxin , chemistry , galactose , biochemistry , oligosaccharide , stereochemistry , microbiology and biotechnology , sialic acid , biology
Glycopolymers mimicking GM1 gangliosides for recognition of cholera toxin B subunit (CTB) were synthesized by a carbohydrate module method. In this method, small carbohydrate fragments constructing oligosaccharides were assumed as “carbohydrate modules” and were incorporated into a polymer for oligosaccharide mimicking. It was shown that the glycopolymer containing both galactose and neuraminic acid displayed enhanced recognition of CTB. The interaction was enhanced by the cooperative binding of both galactose and neuraminic acid to the GM1 binding pocket, and the importance of the close placement of galactose and neuraminic acid groups was revealed. More information can be found in the Full Paper by Yoshiko Miura et al. on page 1021 in Issue 7, 2019 (DOI: 10.1002/asia.201900053).