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Self‐Assembly Behaviors of a Penta‐Phenylene Maltoside and Its Application for Membrane Protein Study
Author(s) -
Ehsan Muhammad,
Kumar Ashwani,
Mortensen Jonas S.,
Du Yang,
Hariharan Parameswaran,
Kumar Kaavya K.,
Ha Betty,
Byrne Bernadette,
Guan Lan,
Kobilka Brian K.,
Loland Claus J.,
Chae Pil Seok
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900224
Subject(s) - phenylene , membrane , micelle , amphiphile , chemistry , aqueous solution , self assembly , membrane protein , fluorescence , fluorescence spectroscopy , polymer chemistry , organic chemistry , combinatorial chemistry , copolymer , polymer , biochemistry , physics , quantum mechanics
We prepared an amphiphile with a penta‐phenylene lipophilic group and a branched trimaltoside head group. This new agent, designated penta‐phenylene maltoside (PPM), showed a marked tendency to self‐assembly into micelles via strong aromatic–aromatic interactions in aqueous media, as evidenced by 1 H NMR spectroscopy and fluorescence studies. When utilized for membrane protein studies, this new agent was superior to DDM, a gold standard conventional detergent, in stabilizing multiple proteins long term. The ability of this agent to form aromatic–aromatic interactions is likely responsible for enhanced protein stabilization when associated with a target membrane protein.