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2‐Phenylquinoline–Sugar Hybrids as Photoswitchable α‐Glucosidase Inhibitors
Author(s) -
Kitamura Takashi,
Okuyama Mai,
Takahashi Daisuke,
Toshima Kazunobu
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900203
Subject(s) - chemistry , photodegradation , sugar , enzyme , lysis , mannose , aqueous solution , biochemistry , organic chemistry , photocatalysis , catalysis
Purpose‐designed 2‐phenylquinoline (PQ)‐sugar hybrids 1 and 2 were synthesized and evaluated for their photodegradation activities against an α‐glucosidase target. The results indicated that PQ‐mannose hybrid 2 selectively and effectively photodegraded α‐glucosidase and significantly inhibited its enzymatic activity upon irradiation with long‐wavelength UV light in the absence of any additives under neutral and aqueous conditions. Furthermore, 2 selectively and effectively inhibited α‐glucosidase activity only with photo‐irradiation even in complex cell lysate.