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Iodine‐promoted Intermolecular Dehydrogenation Diamination: Synthesis of Unsymmetrical α,β‐Diamido Ketones
Author(s) -
Zhang YongJian,
Su Junyi,
Niu Wenjie,
Li Yujin
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201900170
Subject(s) - dehydrogenation , chemistry , iodine , ketone , medicinal chemistry , intermolecular force , amine gas treating , organic chemistry , catalysis , molecule
Iodine‐promoted direct diamination of α,β‐unsaturated ketone to form two C−N bonds has been developed starting from chalcone and secondary amine. This reaction was performed in THF at 50 °C in the presence of I 2 and K 2 CO 3. The protocol is metal‐free, operationally simple and carried out under mild conditions, providing an effective new way for directing diamination reactions.