A Maleimide‐functionalized Tetraphenylethene for Measuring and Imaging Unfolded Proteins in Cells | Zendy

Zhang Shouxiang | Zendy; Liu Mengjie | Zendy; Tan Lewis Yi Fong | Zendy; Hong Quentin | Zendy; Pow Ze Liang | Zendy; Owyong Tze Cin | Zendy; Ding Siyang | Zendy; Wong Wallace W. H. | Zendy; Hong Yuning | Zendy

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A Maleimide‐functionalized Tetraphenylethene for Measuring and Imaging Unfolded Proteins in Cells

Author(s) -

Zhang Shouxiang,

Liu Mengjie,

Tan Lewis Yi Fong,

Hong Quentin,

Pow Ze Liang,

Owyong Tze Cin,

Ding Siyang,

Wong Wallace W. H.,

Hong Yuning

Publication year - 2019

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201900150

Subject(s) - maleimide , chemistry , nanotechnology , biophysics , materials science , polymer chemistry , biology

Collapse of the protein homeostasis (proteostasis) can lead to accumulation and aggregation of unfolded proteins, which has been found to associate with a number of disease conditions including neurodegenerative diseases, diabetes and inflammation. Here we report a maleimide‐functionalized tetraphenylethene (TPE)‐derivatized fluorescent dye, TPE‐NMI, which shows fluorescence turn‐on property upon reacting with unfolded proteins in vitro and in live cells under proteostatic stress conditions. The level of unfolded proteins can be measured by flow cytometry and visualized with confocal microscopy.

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