Cu‐Catalyzed [4+1] Annulation toward Indolo[2,1‐ a ]isoquinolines through Oxidative C(sp 3 )/C(sp 2 )−H Bond Bifunctionalization | Zendy

Zhang TianShu | Zendy; Zhao Qi | Zendy; Hao WenJuan | Zendy; Tu ShuJiang | Zendy; Jiang Bo | Zendy

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Cu‐Catalyzed [4+1] Annulation toward Indolo[2,1‐ a ]isoquinolines through Oxidative C(sp 3 )/C(sp 2 )−H Bond Bifunctionalization

Author(s) -

Zhang TianShu,

Zhao Qi,

Hao WenJuan,

Tu ShuJiang,

Jiang Bo

Publication year - 2019

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201900050

Subject(s) - annulation , catalysis , chemistry , oxidative phosphorylation , aryl , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , alkyl

A Cu‐catalyzed [4+1] annulation of N ‐aryl‐1,2,3,4‐tetrahydroisoquinolines ( N ‐aryl THIQs) with α‐diazoketones has been established under oxidative conditions, leading to the construction of a series of indolo[2,1‐ a ]isoquinolines with generally good yields. The reaction enables dediazotized dicarbonylation of α‐diazoketones, creating direct C(sp 3 )/C(sp 2 )−H bond bifunctionalization to access tetracyclic aza‐heterocyclic skeletons.

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