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Designing Multivalent Ligands to Control Biological Interactions: From Vaccines and Cellular Effectors to Targeted Drug Delivery
Author(s) -
Arsiwala Ammar,
Castro Ana,
Frey Steven,
Stathos Mark,
Kane Ravi S.
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801677
Subject(s) - effector , computational biology , drug delivery , ligand (biochemistry) , targeted drug delivery , drug , chemistry , combinatorial chemistry , receptor , nanotechnology , biology , microbiology and biotechnology , biochemistry , pharmacology , materials science
Multivalent interactions in which multiple ligands on one object bind to multiple receptors on another are commonly found in natural biological systems. In addition, these interactions can lead to increased strength and selectivity when compared to the corresponding monovalent interaction. These attributes have also guided the design of synthetic multivalent ligands to control biological interactions. This review will highlight the recent literature describing the use of multivalent ligand display in the design of vaccines, immunomodulators, cell signaling effectors, and vehicles for targeted drug delivery.