Pd 0 ‐Catalyzed Four‐Component Reaction of Aryl Halide, CO,  N ‐Tosylhydrazone, and Amine | Zendy

Liu Yiyang | Zendy; Zhang Zhen | Zendy; Zhang Songnan | Zendy; Zhang Yan | Zendy; Wang Jianbo | Zendy; Zhang Zhenhua | Zendy

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Pd 0 ‐Catalyzed Four‐Component Reaction of Aryl Halide, CO, N ‐Tosylhydrazone, and Amine

Author(s) -

Liu Yiyang,

Zhang Zhen,

Zhang Songnan,

Zhang Yan,

Wang Jianbo,

Zhang Zhenhua

Publication year - 2018

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201801324

Subject(s) - carbene , chemistry , chemoselectivity , aryl , carbonylation , catalysis , aryl halide , halide , amine gas treating , cascade reaction , ketone , amination , medicinal chemistry , catalytic cycle , organic chemistry , palladium , alkyl , carbon monoxide

A Pd 0 ‐catalyzed four‐component cascade reaction of an aryl halide, CO, an N ‐tosylhydrazone, and an amine affording α‐amino ketone has been developed. This reaction involves a sequential carbonylation, metal carbene migratory insertion, and amination. Control experiments and DFT calculations further reveal the reaction sequence and chemoselectivity of individual components in this cascade process.

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