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Pd 0 ‐Catalyzed Four‐Component Reaction of Aryl Halide, CO, N ‐Tosylhydrazone, and Amine
Author(s) -
Liu Yiyang,
Zhang Zhen,
Zhang Songnan,
Zhang Yan,
Wang Jianbo,
Zhang Zhenhua
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801324
Subject(s) - carbene , chemistry , chemoselectivity , aryl , carbonylation , catalysis , aryl halide , halide , amine gas treating , cascade reaction , ketone , amination , medicinal chemistry , catalytic cycle , organic chemistry , palladium , alkyl , carbon monoxide
A Pd 0 ‐catalyzed four‐component cascade reaction of an aryl halide, CO, an N ‐tosylhydrazone, and an amine affording α‐amino ketone has been developed. This reaction involves a sequential carbonylation, metal carbene migratory insertion, and amination. Control experiments and DFT calculations further reveal the reaction sequence and chemoselectivity of individual components in this cascade process.