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Hydrogen‐Bonding‐Assisted Supramolecular Metal Catalysis
Author(s) -
Mote Nilesh R.,
Chikkali Samir H.
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801302
Subject(s) - supramolecular chemistry , catalysis , hydroformylation , supramolecular catalysis , hydrogen bond , nanotechnology , chemistry , combinatorial chemistry , ligand (biochemistry) , materials science , organic chemistry , rhodium , molecule , biochemistry , receptor
The process of catalyst screening and discovery still largely relies on traditional ligand‐design approaches, which suffer from complex synthetic requirements and offer limited structural diversity. On the contrary, supramolecular chemistry offers the potential to harness multiple weak secondary interactions to deliver self‐assembled catalysts with diverse structures or to orient substrates to achieve enzyme‐like activity and selectivity. Herein, the application of hydrogen‐bonding (H‐bonding) interactions as a construction element and directing group in “supramolecular transition‐metal catalysis” is critically reviewed and the current state‐of‐the‐art in the field is presented. H‐bonding interactions empower structurally simple ligands to deliver complex self‐assembled catalysts, which have been found to catalyze a gamut of organic transformations, including hydroformylation, hydrogenation, and allylation reactions. As we will discuss, on many occasions, these supramolecular catalysts outperform their analogous covalently linked catalytic systems. The potential of H‐bonding interactions as directing groups has recently been recognized by the scientific community and this Focus Review presents the role of hydrogen‐bonding interactions in directing substrates to obtain excellent selectivities and activities in a range of catalytic transformations.