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Pd‐catalyzed Oxidative Cross‐coupling of Alkyl Chromium(0) Fischer Carbene Complexes with Organoboronic Acids
Author(s) -
Wang Kang,
Yang Jinghui,
Yao Xingqi,
Wang Jianbo
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801278
Subject(s) - transmetalation , carbene , organopalladium , chemistry , deprotonation , reductive elimination , alkyl , chromium , aryl , palladium , catalysis , oxidative addition , medicinal chemistry , coupling reaction , organic chemistry , combinatorial chemistry , ion
Abstract Alkyl chromium(0) carbene complexes have been explored as the cross‐coupling partners in the palladium‐catalyzed reaction with aryl or alkenyl boronic acids. This coupling reaction displays the versatile reactivities of alkyl chromium(0) carbenes under palladium catalysis. Mechanistically, this transformation is proposed to involve deprotonation of the alkyl chromium carbene substrate to generate a vinyl chromium anion intermediate that undergoes transmetalation to organopalladium species and reductive elimination.