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Metal‐Free Cross‐Dehydrogenative Coupling (CDC): Molecular Iodine as a Versatile Catalyst/Reagent for CDC Reactions
Author(s) -
Parvatkar Prakash T.,
Manetsch Roman,
Banik Bimal K.
Publication year - 2019
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801237
Subject(s) - reagent , catalysis , chemistry , coupling reaction , combinatorial chemistry , organic synthesis , heteroatom , substrate (aquarium) , iodine , polymer chemistry , organic chemistry , ring (chemistry) , oceanography , geology
The development of ecofriendly methods for carbon–carbon (C−C) and carbon–heteroatom (C−Het) bond formation is of great significance in modern‐day research. Metal‐free cross‐dehydrogenative coupling (CDC) has emerged as an important tool for organic and medicinal chemists as a means to form C−C and C−Het bonds, as it is atom economical and more efficient and greener than transition‐metal catalyzed CDC reactions. Molecular iodine (I 2 ) is recognized as an inexpensive, environmentally benign, and easy‐to‐handle catalyst or reagent to pursue CDCs under mild reaction conditions, with good regioselectivities and broad substrate compatibility. This review presents the recent developments of I 2 ‐catalyzed C−C, C−N, C−O, and C−S/C−Se bond‐forming reactions for the synthesis of various important organic molecules by cross‐dehydrogenative coupling.