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Front Cover: Tug‐of‐War in a Dynamic Helical Peptide: Solvent‐Induced Helix‐Helix Transition of a Lactam‐Bridged Peptide Composed of Point‐ and Axial Chiralities Remote from Each Other (Chem. Asian J. 21/2018)
Author(s) -
Urushima Akio,
Ousaka Naoki,
Yashima Eiji
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801230
Subject(s) - peptide , helix (gastropod) , chirality (physics) , stereochemistry , chemistry , crystallography , physics , biochemistry , biology , ecology , chiral symmetry breaking , quantum mechanics , snail , nambu–jona lasinio model , quark
The axial chirality of an N‐terminal 2,2’‐bipyridine N , N ’‐dioxide bonded to a lactam‐bridged dynamic helical peptide competes against the C‐terminal l ‐Val point chirality for inducing a preferred‐handed helicity in the peptide in the opposite‐handed twisting direction like in a tug‐of‐war. One of the chiralities can be switched (on and off) triggered by a polar solvent, leading to a unique helix‐sense inversion of the peptide backbone. More information can be found in the Communication by Akio Urushima, Naoki Ousaka, and Eiji Yashima on page 3150 in Issue 21, 2018 (DOI: 10.1002/asia.201801111).