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Front Cover: N‐Formylation of Amines with CO 2 and H 2 by Using NHC–Iridium Coordination Assemblies as Solid Molecular Catalysts (Chem. Asian J. 20/2018)
Author(s) -
Zhang Yang,
Wang Jiaquan,
Zhu Haibo,
Tu Tao
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801176
Subject(s) - formamide , catalysis , formylation , iridium , decantation , chemistry , solvent , dimethylformamide , combinatorial chemistry , organic chemistry
NHC–iridium coordination assemblies have been demonstrated as robust, efficient, and recyclable solid molecular catalysts for N‐formylation of various primary and secondary amines with H 2 and CO 2 under mild reaction conditions. A number of formamide derivatives could be synthesized in excellent yields even with chiral unprotected amino alcohols as substrates, and with catalyst loadings as low as 0.1 mol %. Furthermore, N , N ‐dimethylformamide could be formed under solvent‐free conditions even at 0.1 mol % catalyst loading. Remarkably, the solid molecular catalyst could be readily reused via simple centrifugation and decantation without any activating treatments. Having no significant loss of activity after 10 runs highlights the potential of this protocol in industry. More information can be found in the Communication by Tao Tu et al. on page 3018 in Issue 20, 2018 (DOI: 10.1002/asia.201800953).