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Recent Developments in Solid‐Phase Strategies towards Synthetic, Sequence‐Defined Macromolecules
Author(s) -
Hill Stephen A.,
Gerke Christoph,
Hartmann Laura
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801171
Subject(s) - sequence (biology) , macromolecule , solid phase synthesis , polymer , phase (matter) , nanotechnology , synthetic polymer , function (biology) , materials science , computer science , chemistry , biology , organic chemistry , peptide , biochemistry , evolutionary biology , composite material
Sequence‐control in synthetic polymers is an important contemporary research area because it provides the opportunity to create completely novel materials for structure–function studies. This is especially relevant for biomimetic polymers, bioactive and information security materials. The level of control is strongly dependent and inherent upon the polymerization technique utilized. Today, the most established method yielding monodispersity and monomer sequence‐definition is solid‐phase synthesis. This Focus Review highlights recent advances in solid‐phase strategies to access synthetic, sequence‐defined macromolecules. Alternatives strategies towards sequence‐defined macromolecules are also briefly summarized.