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Peroxisome‐targeted Supramolecular Nanoprobes Assembled with Pyrene‐labelled Peptide Amphiphiles
Author(s) -
Kim Inhye,
Bang WooYoung,
Kim Sooyong,
Jin SeonMi,
Hyun JuYong,
Han Eun Hee,
Lee Eunji
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800863
Subject(s) - peroxisome , supramolecular chemistry , amphiphile , peptide , chemistry , pyrene , biochemistry , tripeptide , combinatorial chemistry , receptor , organic chemistry , crystal structure , copolymer , polymer
Despite the versatile metabolic functions of peroxisomes such as lipid synthesis and fatty acid oxidation and their relevance to genetically inherited diseases, namely, peroxisome biogenesis disorders and peroxisomal enzyme deficiency, there is not much research on peroxisome‐targeting therapeutics. Herein we present supramolecular nanostructured probes based on the self‐assembly of peptide amphiphiles (PAs) having peroxisome‐targeting ability in mammalian cells. The PA was designed to include the peroxisome‐targeting tripeptide (SKL) and a fluorescent dye (pyrene). It was revealed that the presence of the SKL‐appended carboxyl terminal group of PA, the extent of α‐helical nature of the peptide block, and the fibrillar morphology of nano‐assemblies affected the targeting efficiency of PA supramolecular nanoprobe. The simple modification of PAs by the peroxisome‐targeting strength prediction showed an enhanced peroxisome specificity, as expected. This work provides important insights into designing subcellular organelle‐targeting nanoparticles for next‐generation nanomedicines.