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A Peptide‐Based Supramolecular Hydrogel for Controlled Delivery of Amine Drugs
Author(s) -
Wang Youzhi,
Zhang Yiming,
Li Xinxin,
Li Can,
Yang Zhimou,
Wang Ling
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800708
Subject(s) - self healing hydrogels , supramolecular chemistry , drug delivery , amine gas treating , peptide , combinatorial chemistry , chemistry , aldehyde , controlled release , aqueous solution , nanotechnology , materials science , polymer chemistry , organic chemistry , biochemistry , molecule , catalysis
Supramolecular hydrogels hold great promise for controlled drug delivery. Herein we report a supramolecular hydrogel based on a peptide bearing a terminal aldehyde. The hydrogel was prepared via an enzyme instructed self‐assembly (EISA) process, and the resulting hydrogels showed ultra‐stable properties in highly acidic or basic aqueous solutions. The hydrogelator could form Schiff bases with amine drugs. Owing to the pH‐responsive properties of Schiff bases, the hydrogels could be used for controlled release of encapsulated amine drugs. Our study provides a peptide‐based hydrogel that may be applied for controlled drug delivery.