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Pd II ‐Catalyzed Cascade Synthesis of Chromane Derivatives Initiated by cis ‐Chloropalladation or trans ‐Acetoxypalladation
Author(s) -
Shukla Rahul K.,
Pal Kuntal,
Volla Chandra M. R.
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800649
Subject(s) - cascade , catalysis , chemistry , medicinal chemistry , stereochemistry , organic chemistry , chromatography
A highly regio‐ and stereoselective Pd II ‐catalyzed cascade synthesis of biologically relevant chromane derivatives from easily available enynes was developed under operationally simple conditions. The cascade reaction consists of nucleopalladation of alkynes, insertion of the alkene and protonation. When CuCl 2 was employed as nucleophile, a cis ‐chloropalladation initiates the cascade. Whereas in the case of AcOH, a trans ‐acetoxypalladation takes place.