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Controlled Release of RNAi Molecules by Tunable Supramolecular Hydrogel Carriers
Author(s) -
Bakker Maarten H.,
van Rooij Eva,
Dankers Patricia Y. W.
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800582
Subject(s) - supramolecular chemistry , rna interference , drug delivery , controlled release , chemistry , microrna , molecule , nanotechnology , small molecule , materials science , biophysics , biochemistry , biology , organic chemistry , gene , rna
Local, sustained release and presentation of RNAi therapeutics can be achieved with hydrogel delivery systems. Here we show the development of a supramolecular hydrogel into a local RNAi delivery system. By careful material design, two simple but effective strategies are introduced to obtain controlled release of two classes of RNAi therapeutics, that is, microRNA and antimiR. It was shown that the release of microRNA could be regulated using cholesterol‐modification for interaction with the supramolecular hydrogel. Non‐modified antimiR release could be controlled via supramolecular introduction of positively charged additive molecules into the supramolecular hydrogel. In this way, either the cholesterol‐modification on the drug or the charge introduction into the hydrogel provides handles for controlled RNAi therapy.