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Enantiospecific Suzuki–Miyaura Coupling of Nonbenzylic α‐(Acylamino)alkylboronic Acid Derivatives
Author(s) -
Ohmura Toshimichi,
Miwa Kyoko,
Awano Tomotsugu,
Suginome Michinori
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800536
Subject(s) - halide , aryl , chemistry , catalysis , aryl halide , inversion (geology) , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , palladium , alkyl , biology , paleontology , structural basin
Suzuki–Miyaura coupling of nonbenzylic α‐(acylamino)alkylboron compounds with aryl halides is established. A Pd/PCy 2 Ph catalyst promotes the reaction efficiently at 145 °C. The reaction of enantioenriched α‐(acylamino)alkylboron compounds affords chiral 1‐arylalkylamides in high enantiospecificity and inversion of configuration.