Enantiospecific Suzuki–Miyaura Coupling of Nonbenzylic α‐(Acylamino)alkylboronic Acid Derivatives | Zendy

Ohmura Toshimichi | Zendy; Miwa Kyoko | Zendy; Awano Tomotsugu | Zendy; Suginome Michinori | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Enantiospecific Suzuki–Miyaura Coupling of Nonbenzylic α‐(Acylamino)alkylboronic Acid Derivatives

Author(s) -

Ohmura Toshimichi,

Miwa Kyoko,

Awano Tomotsugu,

Suginome Michinori

Publication year - 2018

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201800536

Subject(s) - halide , aryl , chemistry , catalysis , aryl halide , inversion (geology) , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , palladium , alkyl , biology , paleontology , structural basin

Suzuki–Miyaura coupling of nonbenzylic α‐(acylamino)alkylboron compounds with aryl halides is established. A Pd/PCy 2 Ph catalyst promotes the reaction efficiently at 145 °C. The reaction of enantioenriched α‐(acylamino)alkylboron compounds affords chiral 1‐arylalkylamides in high enantiospecificity and inversion of configuration.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research