Premium
Super‐quenched Molecular Probe Based on Aggregation‐Induced Emission and Photoinduced Electron Transfer Mechanisms for Formaldehyde Detection in Human Serum
Author(s) -
Yang Haitao,
Wang Fujia,
Zheng Jilin,
Lin Hao,
Liu Bin,
Tang YiDa,
Zhang ChongJing
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800530
Subject(s) - fluorescence , photochemistry , photoinduced electron transfer , quenching (fluorescence) , intramolecular force , analyte , chemistry , electron transfer , formaldehyde , energy transfer , aggregation induced emission , chemical physics , optics , organic chemistry , physics
Energy transfer between fluorescent dyes and quenchers is widely used in the design of light‐up probes. Although dual quenchers are more effective in offering lower background signals and higher turn‐on ratios than one quencher, such probes are less explored in practice as they require both quenchers to be within the proximity of the fluorescent core. In this contribution, we utilized intramolecular motion and photoinduced electron transfer (PET) as quenching mechanisms to build super‐quenched light‐up probes based on fluorogens with aggregation‐induced emission. The optimized light‐up probe possesses negligible background and is able to detect not only free formaldehyde (FA) but also polymeric FA, with an unprecedented turn‐on ratio of >4900. We envision that this novel dual quenching strategy will help to develop various light‐up probes for analyte sensing.