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Copper/Diboron‐Mediated Intramolecular Oxygenation and Allylation/Benzylation of Nitroalkynes for the Synthesis of C2‐Quaternary Indolin‐3‐ones
Author(s) -
Fu Wenqiang,
Zhou Yao,
Song Qiuling
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800500
Subject(s) - intramolecular force , chemistry , cycloisomerization , functional group , oxygenation , copper , combinatorial chemistry , catalysis , organic chemistry , ecology , biology , polymer
A direct strategy for intramolecular transfer oxygenation of alkynes and cycloisomerization of 2‐nitroalkynes to synthesize a wide range of C2‐quaternary indolin‐3‐ones was developed by a copper/diboron system. The desired allylation, benzylation and propargylation products were obtained in moderate to excellent yields with good functional group tolerance. The mechanism study indicated that this protocol involved a radical process.