Nickel‐Catalyzed Asymmetric [2+2] Cycloaddition Reaction of Hetero‐Bicyclic Alkenes with Internal Alkynes | Zendy

Qin Hongyu | Zendy; Chen Jingchao | Zendy; Li Kangkui | Zendy; He Zhenxiu | Zendy; Zhou Yongyun | Zendy; Fan Baomin | Zendy

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Nickel‐Catalyzed Asymmetric [2+2] Cycloaddition Reaction of Hetero‐Bicyclic Alkenes with Internal Alkynes

Author(s) -

Qin Hongyu,

Chen Jingchao,

Li Kangkui,

He Zhenxiu,

Zhou Yongyun,

Fan Baomin

Publication year - 2018

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201800492

Subject(s) - cycloaddition , catalysis , bicyclic molecule , enantioselective synthesis , chemistry , nickel , medicinal chemistry , combinatorial chemistry , organic chemistry

Enantioselective [2+2] cycloaddition reaction of azabenzonorbornadienes and oxabenzonorbornadienes with internal alkynes has been enabled by a catalyst system comprising Ni(COD) 2 and ( R )‐SIPHOS‐Ph‐Mor. This transformation represents the first asymmetric [2+2] cycloaddition reaction of azabenzonorbornadienes with internal alkynes, providing a straightforward method to prepare four‐membered carbocycles.

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