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Nickel‐Catalyzed Asymmetric [2+2] Cycloaddition Reaction of Hetero‐Bicyclic Alkenes with Internal Alkynes
Author(s) -
Qin Hongyu,
Chen Jingchao,
Li Kangkui,
He Zhenxiu,
Zhou Yongyun,
Fan Baomin
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800492
Subject(s) - cycloaddition , catalysis , bicyclic molecule , enantioselective synthesis , chemistry , nickel , medicinal chemistry , combinatorial chemistry , organic chemistry
Enantioselective [2+2] cycloaddition reaction of azabenzonorbornadienes and oxabenzonorbornadienes with internal alkynes has been enabled by a catalyst system comprising Ni(COD) 2 and ( R )‐SIPHOS‐Ph‐Mor. This transformation represents the first asymmetric [2+2] cycloaddition reaction of azabenzonorbornadienes with internal alkynes, providing a straightforward method to prepare four‐membered carbocycles.