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Metal‐Free Allylic Oxidation of Steroids Using TBAI/TBHP Organocatalytic Protocol
Author(s) -
Lam YingPong,
Yeung YingYeung
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800256
Subject(s) - allylic rearrangement , chemistry , protocol (science) , metal , combinatorial chemistry , catalysis , organic chemistry , medicine , alternative medicine , pathology
A mild, efficient and organocatalytic allylic oxidation of steroids using a TBAI/TBHP protocol has been developed. A range of bioactive Δ 5 ‐en‐7‐ones can be easily prepared from the corresponding Δ 5 ‐steroids. The methodology features several advantages, including readily available starting materials, environmentally benign oxidant, high functional group compatibility, and metal‐free catalysis.