Iodine‐Mediated Direct Generation of  o ‐Quinone Methides at Room Temperature: A Facile Protocol for the Synthesis of  ortho ‐Hydroxybenzyl Thioethers | Zendy

Basha R. Sidick | Zendy; Chen ChiaWei | Zendy; Reddy Daggula Mallikarjuna | Zendy; Lee ChinFa | Zendy

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Iodine‐Mediated Direct Generation of o ‐Quinone Methides at Room Temperature: A Facile Protocol for the Synthesis of ortho ‐Hydroxybenzyl Thioethers

Author(s) -

Basha R. Sidick,

Chen ChiaWei,

Reddy Daggula Mallikarjuna,

Lee ChinFa

Publication year - 2018

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201800233

Subject(s) - iodine , chemistry , quinone , bond cleavage , halogen , thio , combinatorial chemistry , organic chemistry , catalysis , alkyl

An iodine‐mediated preparation of ortho ‐quinone methides ( o ‐QMs) from ortho ‐hydroxybenzyl alcohols by a C−O bond scission strategy is described. The in situ generated o ‐QMs were then employed for C−S bond formation by thio‐Michael addition of thiols to provide the ortho ‐hydroxybenzyl thioethers ( o ‐HBT) in moderate to excellent yields.

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