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Facile N‐Alkylation/N′‐Arylation Process: A Direct Approach to Aromatic Aminoalkyl Amines
Author(s) -
Zhu Qiming,
Chen Mingwei,
Hu Jinyu,
Yang Luyi
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800193
Subject(s) - alkylation , halide , chemistry , alkyl , aryl , cyclic amines , catalysis , cleavage (geology) , tertiary amine , amine gas treating , organic chemistry , molecule , combinatorial chemistry , nitrogen , medicinal chemistry , materials science , fracture (geology) , composite material
An intriguing C−N transformation involving a catalyst‐free N‐alkylation/N′‐arylation process in a multicomponent reaction with secondary amines, cyclic tertiary amines and electron‐deficient aryl halides has been described. In this case, the N‐alkylation of secondary amines, utilizing cyclic tertiary amines as alkyl group sources, is enabled by a facile C−N cleavage. Such an operationally simple method could facilitate access to aromatic aminoalkyl amines, nitrogen‐containing bioactive molecules, in good to excellent yields.