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Diastereo‐ and Enantioselective Palladium‐Catalyzed Dearomative [3+2] Cycloaddition of 3‐Nitroindoles
Author(s) -
Suo JiaJia,
Liu Wei,
Du Juan,
Ding ChangHua,
Hou XueLong
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800133
Subject(s) - enantioselective synthesis , aziridine , cycloaddition , catalysis , palladium , ligand (biochemistry) , chemistry , combinatorial chemistry , organic chemistry , ring (chemistry) , biochemistry , receptor
Diastereo‐ and enantioselective cycloaddition of 3‐nitroindoles with vinyl aziridine was realized under Pd‐catalysis using commercially available Walphos as the ligand, affording pyrroloindolines in high yields with high diastereo‐ and enantioselectivities. The reaction can be scaled up to a gram scale and the reaction products are easily converted to amino pyrroloindoline and other pyrroloindoline derivatives.