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Triphenylamine‐Appended Half‐Sandwich Iridium(III) Complexes and Their Biological Applications
Author(s) -
He Xiangdong,
Tian Meng,
Liu Xicheng,
Tang Yanhua,
Shao Chang Fang,
Gong Peiwei,
Liu Jinfeng,
Zhang Shumiao,
Guo Lihua,
Liu Zhe
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800103
Subject(s) - nad+ kinase , triphenylamine , chemistry , bovine serum albumin , ligand (biochemistry) , cytotoxicity , nicotinamide adenine dinucleotide , iridium , reactive oxygen species , cisplatin , stereochemistry , medicinal chemistry , in vitro , polymer chemistry , biochemistry , enzyme , catalysis , biology , receptor , chemotherapy , genetics
Organometallic half‐sandwich Ir III complexes of the type [(η 5 ‐Cp x )Ir(N^N)Cl]PF 6 (Cp x : Cp* or its phenyl Cp xph or biphenyl Cp xbiph derivatives; N^N: triphenylamine (TPA)‐substituted bipyridyl ligand groups) were synthesized and characterized. The complexes showed excellent bovine serum albumin (BSA) and DNA binding properties and were able to oxidize NADH to NAD + (NAD=nicotinamide adenine dinucleotide) efficiently. The complexes induced apoptosis effectively and led to the emergence of reactive oxygen species (ROS) in cells. All complexes showed potent cytotoxicity with IC 50 values ranging from 1.5 to 7.1 μ m toward A549 human lung cancer cells after 24 hours of drug exposure, which is up to 14 times more potent than cisplatin under the same conditions.