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Front Cover: Silver‐Catalyzed Efficient Synthesis of Oxindoles and Pyrroloindolines via α‐Aminoalkylation of N ‐Arylacrylamides with Amino Acid Derivatives (Chem. Asian J. 5/2018)
Author(s) -
Kanyiva Kyalo Stephen,
Makino Sohei,
Shibata Takanori
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201800100
Subject(s) - catalysis , amino acid , chemistry , organic synthesis , combinatorial chemistry , divergent synthesis , organic chemistry , biochemistry
Amino acids are readily available , stable, structurally variable, and inexpensive, making them attractive starting materials for synthesis of complex organic compounds. As shown on the cover picture, α‐amino acids were used as precursors for the concise synthesis of oxindoles using silver‐catalyzed decarboxylative radical addition to N ‐aryl acrylamides. The α‐aminoalkylation tolerates a broad scope of functional groups often used in organic synthesis. Moreover, the synthesized oxindoles were readily transformed into densely functionalized pyrroloindolines by deprotection and cyclization. More information can be found in the Communication by Kyalo Stephen Kanyiva et al. on page 496 in Issue 5, 2018 (DOI: 10.1002/asia.201701739).