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Silver‐Catalyzed Efficient Synthesis of Oxindoles and Pyrroloindolines via α‐Aminoalkylation of N ‐Arylacrylamides with Amino Acid Derivatives
Author(s) -
Kanyiva Kyalo Stephen,
Makino Sohei,
Shibata Takanori
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701739
Subject(s) - catalysis , chemistry , amino acid , combinatorial chemistry , organic chemistry , reaction conditions , biochemistry
α‐Aminoalkylation of N ‐arylacrylamides with amino acid derivatives was achieved by silver‐catalysis in moderate to high yields. The reaction provides an efficient strategy for the synthesis of functionalized oxindoles, and is suitable for a wide range of N ‐arylacrylamides and amino acids, both of which are inexpensive and readily available. The oxindoles obtained were readily transformed into densely functionalized pyrroloindolines by deprotection and cyclization in one pot.