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Nickel‐Catalyzed Heck‐Type Monofluoroacetation of Styrenes for Facile Synthesis of Allylic Fluorides
Author(s) -
Wang ZhenYu,
Wan JiaHao,
Wang GaoYin,
Jin RuoXing,
Lan Quan,
Wang XiSheng
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701655
Subject(s) - catalysis , nickel , allylic rearrangement , stereoselectivity , substrate (aquarium) , heck reaction , chemistry , combinatorial chemistry , catalytic cycle , scope (computer science) , transformation (genetics) , organic chemistry , palladium , computer science , biochemistry , oceanography , gene , geology , programming language
An efficient nickel‐catalyzed Heck‐type reaction between styrenes and fluoroalkyl iodine has been developed. This novel transformation has demonstrated a broad substrate scope, mild reaction conditions and excellent E ‐stereoselectivity. This efficient synthetic method has been applied to the late‐stage monofluoroacetation of biologically active molecules. Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.