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Rational Design of [ 13 C,D 14 ] Tert ‐butylbenzene as a Scaffold Structure for Designing Long‐lived Hyperpolarized 13 C Probes
Author(s) -
Imakura Yuki,
aka Hiroshi,
Takakusagi Yoichi,
Ichikawa Kazuhiro,
Maptue Nesmine R.,
Funk Alexander M.,
Khemtong Chalermchai,
Sando Shinsuke
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701652
Subject(s) - hyperpolarization (physics) , polarization (electrochemistry) , population , chemistry , spin–lattice relaxation , molecule , relaxation (psychology) , nuclear magnetic resonance , spin (aerodynamics) , nuclear magnetic resonance spectroscopy , physics , psychology , social psychology , demography , organic chemistry , sociology , nuclear quadrupole resonance , thermodynamics
Dynamic nuclear polarization (DNP) is a technique to polarize the nuclear spin population. As a result of the hyperpolarization, the NMR sensitivity of the nuclei in molecules can be dramatically enhanced. Recent application of the hyperpolarization technique has led to advances in biochemical and molecular studies. A major problem is the short lifetime of the polarized nuclear spin state. Generally, in solution, the polarized nuclear spin state decays to a thermal spin equilibrium, resulting in loss of the enhanced NMR signal. This decay is correlated directly with the spin‐lattice relaxation time T 1 . Here we report [ 13 C,D 14 ] tert ‐butylbenzene as a new scaffold structure for designing hyperpolarized 13 C probes. Thanks to the minimized spin‐lattice relaxation ( T 1 ) pathways, its water‐soluble derivative showed a remarkably long 13 C T 1 value and long retention of the hyperpolarized spin state.