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Transition‐Metal‐Catalyzed Cyanation by Using an Electrophilic Cyanating Agent, N ‐Cyano‐ N ‐phenyl‐ p ‐toluenesulfonamide (NCTS)
Author(s) -
Cui Jie,
Song Jian,
Liu Qing,
Liu Hui,
Dong Yunhui
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201701611
Subject(s) - cyanation , electrophile , nitrile , nucleophile , reagent , chemistry , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry
The ability to introduce a nitrile group into a biologically active compound is very useful in organic synthesis, owing to the importance of nitrile groups in transformations and tuning molecular properties. To date, nucleophilic cyanation has been the most used strategy for this purpose, whilst electrophilic cyanation reactions are less developed. Recently, the electrophilic cyanation reagent N ‐cyano‐ N ‐phenyl‐ p ‐toluenesulfonamide (NCTS) has received increasing attention, owing to its superior properties in terms of safety and practicality. This Focus Review summarizes recent progress in transition‐metal‐catalyzed cyanation reactions that use NCTS.